A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Br J Cancer. 1984 Jul;50(1):23-30. doi: 10.1038/bjc.1984.135.


The metastatic sites of infiltrating duct (IDC) and infiltrating lobular carcinoma (ILC) have been compared using both clinical and autopsy data. The following statistically significant differences were found: Lung parenchymal metastases were more common in IDC. Bone trephine biopsies were more likely to be positive in ILC. Carcinomatous meningitis was associated almost exclusively with ILC. Peritoneal/retroperitoneal metastases of distinctive pattern occurred in ILC. There was often associated linitis plastica-like involvement of the stomach wall and diffuse infiltration of the uterus. Hydronephrosis was a common secondary phenomenon.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bone Neoplasms / secondary
  • Breast Neoplasms / pathology*
  • Carcinoma / pathology
  • Carcinoma / secondary*
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Carcinoma, Intraductal, Noninfiltrating / secondary*
  • Female
  • Humans
  • Lung Neoplasms / secondary
  • Meningeal Neoplasms / secondary
  • Middle Aged
  • Neoplasm Metastasis / pathology*
  • Peritoneal Neoplasms / secondary
  • Retroperitoneal Neoplasms / secondary