Suppression of cellular and humoral immunity to T-dependent antigens by calorie restriction

Cell Immunol. 1984 Oct 1;88(1):1-8. doi: 10.1016/0008-8749(84)90046-7.


Calorie restriction is known to preserve the immunologic function and prolong the life span of autoimmune-susceptible mice. In order to determine the influence of calorie restriction on cellular and humoral immunity, we tested lymphocyte proliferative response and antibody response to T-dependent antigens in C57Bl/6 mice maintained on restricted diets. C57Bl/6 mice fed a low-calorie diet demonstrated a marked reduction in T-dependent-antigen-specific lymphocyte proliferation and antibody response when compared to mice fed ad libitum. The depressed lymphocyte response seen in calorie-restricted animals is attributed to a defect in both the macrophages and T cells in antigen processing, presentation, and/or proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Autoantibodies / biosynthesis
  • Dose-Response Relationship, Immunologic
  • Energy Intake*
  • Immune Tolerance*
  • Lymphocyte Activation
  • Macrophages / immunology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Cholinergic / immunology
  • T-Lymphocytes / immunology*


  • Autoantibodies
  • Receptors, Cholinergic