Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism

Int J Nucl Med Biol. 1984;11(2):121-8. doi: 10.1016/0047-0740(84)90047-0.


Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood. 11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart. A rapid and reliable method for producing [11C]palmitic acid from [11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Carbon Radioisotopes*
  • Dogs
  • Heart / diagnostic imaging*
  • Indicators and Reagents
  • Myocardium / metabolism*
  • Palmitic Acid
  • Palmitic Acids* / chemical synthesis
  • Tomography, Emission-Computed


  • Carbon Radioisotopes
  • Indicators and Reagents
  • Palmitic Acids
  • Palmitic Acid