Abstract
Weanling vitamin D-deficient rats fed a high calcium, low phosphate diet were injected daily with 1 alpha-hydroxyergocalciferol or 1 alpha-hydroxycholecalciferol at doses of 2.5, 25 or 250 ng. Intestinal calcium and phosphate transport, serum phosphorus level, epiphyseal plate calcification, and percent femur ash increased as a function of the dose. Both compounds were equally effective in eliciting these responses demonstrating their equivalency as antirachitic compounds.
MeSH terms
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Animals
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Biological Transport / drug effects
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Body Weight / drug effects
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Bone and Bones / drug effects
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Bone and Bones / metabolism
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Calcium / blood
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Calcium / metabolism
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Ergocalciferols / analogs & derivatives*
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Ergocalciferols / pharmacology
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Hydroxycholecalciferols / pharmacology*
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Intestinal Absorption / drug effects
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Male
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Phosphates / blood
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Phosphates / metabolism
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Rats
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Rats, Inbred Strains
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Rickets / prevention & control*
Substances
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Ergocalciferols
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Hydroxycholecalciferols
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Phosphates
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1 alpha-hydroxyergocalciferol
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Calcium
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alfacalcidol