On the construction of functional maps in positron emission tomography

J Cereb Blood Flow Metab. 1984 Dec;4(4):629-32. doi: 10.1038/jcbfm.1984.89.


A linear algorithm for the rapid calculation of local rate constants is proposed. The method is applicable to the three-compartment models currently used in the analysis of positron camera measurements with [11C]methionine, [11C]deoxyglucose, and [11C]glucose. The same technique can also be used for the regional measurement of local blood flow with the aid of a freely diffusible tracer. The algorithm was applied to measurements on humans with [11C]glucose. As a comparison, the same data were also analyzed with a standard nonlinear technique. Good agreement between the two methods was obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism
  • Brain / physiology
  • Carbon Radioisotopes
  • Deoxyglucose / metabolism
  • Glucose / metabolism
  • Humans
  • Methionine / metabolism
  • Tomography, Emission-Computed / methods*


  • Carbon Radioisotopes
  • Deoxyglucose
  • Methionine
  • Glucose