Complexity of human T-cell antigen receptor beta-chain constant- and variable-region genes

Nature. 1984 Dec 6-12;312(5994):541-5. doi: 10.1038/312541a0.


Immune systems of vertebrates function via two types of effector cells, B and T cells, which are capable of antigen-specific recognition. The immunoglobulins, which serve as antigen receptors on B cells, have been well characterized with respect to gene structure, unlike the T-cell receptors. Recently, cDNA clones thought to correspond to the beta-chain locus of the human and mouse T-cell receptor have been described. The presumptive beta-chain clones detect gene rearrangement specifically in T-cell DNA and show homology with immunoglobulin light chains. The similarity of the T-cell beta-chain gene system to the immunoglobulin genes has been further demonstrated by the recent observation of variable- and constant-region gene segments as well as joining segments and putative diversity segments. We report here the characterization of cDNA and genomic clones encoding human T-cell receptor beta-chain genes. There are two constant-region genes (C beta 1 and C beta 2), each capable of rearrangement and expression as RNA. The gene arrangement, analogous to that of mouse beta-chain genes, shows strong evolutionary conservation of the dual C beta gene system in these two species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biological Evolution
  • Cell Line
  • Genes
  • Humans
  • Immunoglobulins / genetics
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell / genetics*
  • Recombination, Genetic
  • T-Lymphocytes / physiology*


  • Immunoglobulins
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/K02884
  • GENBANK/K02885