Induction of c-fos gene and protein by growth factors precedes activation of c-myc

Nature. 1984 Dec 20-1985 Jan 2;312(5996):716-20. doi: 10.1038/312716a0.


Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.

MeSH terms

  • Animals
  • Cell Division / drug effects*
  • Cell Transformation, Viral / drug effects
  • Cycloheximide / pharmacology
  • Epidermal Growth Factor / pharmacology
  • Fibroblast Growth Factors / pharmacology
  • Gene Expression Regulation / drug effects
  • Growth Substances / pharmacology*
  • Kinetics
  • Mice
  • Oncogenes*
  • Platelet-Derived Growth Factor / pharmacology
  • Transcription, Genetic / drug effects


  • Growth Substances
  • Platelet-Derived Growth Factor
  • Fibroblast Growth Factors
  • Epidermal Growth Factor
  • Cycloheximide