Antibodies to dsDNA and ssDNA in the immunoglobulin classes IgG and IgM: prognostic value in the course of SLE

Z Rheumatol. 1984 Sep-Oct;43(5):265-71.


Antibodies to dsDNA of the IgG-class show a strong association with disease activity in the course of systemic lupus erythematosus (SLE). Of 22 patients with low dsDNA-levels only one had an exacerbation. In 8 patients a rise of IgG-dsDNA antibodies to high levels occurred, followed by an exacerbation in 7 of them. In 6 of these 7 patients the IgG-dsDNA antibodies had a prognostic value by rising into high ranges 2-12 weeks before the exacerbation. IgG-ssDNA antibodies showed only a weak association to the clinical course. IgM antibodies to dsDNA as well as to ssDNA did not correlate with the clinical activity at all.

MeSH terms

  • Antibodies, Antinuclear / metabolism*
  • DNA / immunology*
  • DNA, Single-Stranded / immunology*
  • Humans
  • Immunoglobulin G / metabolism*
  • Immunoglobulin M / metabolism*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology*
  • Prognosis


  • Antibodies, Antinuclear
  • DNA, Single-Stranded
  • Immunoglobulin G
  • Immunoglobulin M
  • deoxyribonucleoprotein antibodies
  • DNA