Anti-inflammatory and analgesic properties of four amino-acids

Indian J Physiol Pharmacol. Oct-Dec 1984;28(4):299-305.

Abstract

Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.

MeSH terms

  • Amino Acids / pharmacology*
  • Amino Acids / toxicity
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal*
  • Carrageenan
  • Diarrhea / prevention & control
  • Edema / drug therapy
  • Female
  • Granuloma / drug therapy
  • Male
  • Phenylbutazone / pharmacology
  • Rats

Substances

  • Amino Acids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Carrageenan
  • Phenylbutazone