Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes

Nature. 1984 Aug 2-8;310(5976):387-91. doi: 10.1038/310387a0.

Abstract

The genomic structure of the joining (J) and constant (C) regions of the locus encoding the beta-chain of the murine T-cell receptor has been analysed. The gene segments are arranged tandemly (J-C/J-C) within a 15-kilobase region. The two constant-region genes are almost identical, differing by only four amino acids, all in carboxy-terminal portions. Each C region comprises four exons encoding an external globular domain, a small hinge-like region, a transmembrane region and a cytoplasmic tail plus 3'-untranslated region. The two clusters of J regions each contain 7 distinct elements, 12 of which may be functional.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Genes
  • Macromolecular Substances
  • Mice
  • Receptors, Antigen, T-Cell / genetics*

Substances

  • Macromolecular Substances
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/M23825
  • GENBANK/M23826
  • GENBANK/M23827