Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

J Bacteriol. 1983 Feb;153(2):1079-82. doi: 10.1128/jb.153.2.1079-1082.1983.

Abstract

Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalase / metabolism
  • Escherichia coli / drug effects*
  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • Exodeoxyribonucleases / physiology*
  • Hydrogen Peroxide / pharmacology*
  • Mutation
  • Phenotype

Substances

  • Hydrogen Peroxide
  • Catalase
  • Exodeoxyribonucleases
  • exodeoxyribonuclease III