Immunology of pyelonephritis in the primate model. VI. Effect of complement depletion

J Urol. 1983 Jan;129(1):193-6. doi: 10.1016/s0022-5347(17)51981-3.

Abstract

The inflammatory response has been shown to be responsible for the renal damage from bacterial infection. Phagocytic events are responsible for damage to the host as well as the pathogen. In this study we evaluated the effect of complement depletion, in an attempt to decrease chemotaxis and opsonization and thus decrease phagocytosis. Acute renal damage was decreased from both a decrease in inflammatory cells and phagocytic events in the areas of bacterial inoculation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chemotaxis, Leukocyte
  • Complement C3 / physiology
  • Complement System Proteins / physiology*
  • Elapid Venoms / pharmacology
  • Escherichia coli Infections / immunology
  • Female
  • Inflammation / immunology
  • Lymphocytes / immunology
  • Macaca fascicularis
  • Phagocytosis
  • Pyelonephritis / immunology*
  • Pyelonephritis / pathology

Substances

  • Complement C3
  • Elapid Venoms
  • cobra venom factor
  • Complement System Proteins