Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections

J Pediatr. 1983 Apr;102(4):623-7. doi: 10.1016/s0022-3476(83)80207-8.


Forty-nine ambulatory children between 2-1/2 and 12 years of age with acute, clinically uncomplicated urinary tract infections caused by susceptible organisms were randomized to receive a single dose of amoxicillin based on weight or a 10-day course of amoxicillin therapy (conventional therapy). Patients receiving single doses of amoxicillin had a cure rate of 63%, which compares unfavorably with the cure rate of 92% in patients given conventional therapy. A failure of single-dose therapy predicted underlying radiologic abnormalities with a sensitivity of 60% and a specificity of 58%, making it a poor screening test for detecting those patients at risk for renal parenchymal damage. The antibody-coated bacteria assay had no predictive value in separating upper and lower tract disease, although it may predict underlying radiologic abnormalities. The data indicate that the response to single-dose amoxicillin therapy fails to separate upper from lower tract disease reliably and has a limited role in predicting response to conventional antimicrobial therapy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Amoxicillin / administration & dosage*
  • Amoxicillin / therapeutic use
  • Antibody-Coated Bacteria Test, Urinary
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / drug therapy
  • Female
  • Humans
  • Male
  • Random Allocation
  • Risk
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / etiology


  • Amoxicillin