Immunological studies in two children with recurrent parotitis

Acta Paediatr Scand. 1983 Mar;72(2):265-8. doi: 10.1111/j.1651-2227.1983.tb09709.x.

Abstract

In two children with recurrent parotitis, labial salivary gland biopsies showed chronic sialoadenitis. Immunofluorescence studies disclosed deposits of immunoglobulins and complement in juxta-acinar small vessels. Case 1 had gluten enteropathy, IgA deficiency and high titres of antinuclear antibodies (ANA), and in vivo fixation of ANA to nuclei of different cells in lip, skin and jejunum was present. Case 2 showed deposition of IgM in the dermo-epidermal junction of the skin. These findings suggest that autoimmune reactivity and immune complexes may play a role in the pathogenesis of this disorder.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Blood Proteins / analysis
  • Child
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulins / analysis
  • Parotitis / immunology*
  • Recurrence
  • Salivary Glands / pathology

Substances

  • Blood Proteins
  • Immunoglobulins