Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I (insulin-dependent) diabetics

J Clin Endocrinol Metab. 1983 Jun;56(6):1306-12. doi: 10.1210/jcem-56-6-1306.


The release of immunoreactive gastric inhibitory polypeptide (IR-GIP) in response to a standard meal was examined in 10 normal subjects and 15 type I (insulin-dependent) diabetics 7 days (test I), 14 days (test II), and 3 months (test III) after time of diagnosis. During all three tests, the diabetics had significantly lower plasma IR-GIP concentrations than the controls from 15-90 min after the standard meal. The IR-GIP response in the diabetics measured as the integrated area under the response curve corresponded to 70% of that of normal subjects. beta-cell function evaluated from the C-peptide response to the meal increased significantly from test I to test III whereas the IR-GIP response was similar during all three tests. As GIP is known to potentiate glucose-induced insulin secretion and possibly the biosynthesis of insulin, the low IR-GIP responses in subjects with type I diabetes may significantly influence insulin levels and hyperglycemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / metabolism*
  • Diet
  • Food*
  • Gastric Inhibitory Polypeptide / metabolism*
  • Gastrointestinal Hormones / metabolism*
  • Humans
  • Insulin / blood
  • Time Factors


  • Blood Glucose
  • C-Peptide
  • Gastrointestinal Hormones
  • Insulin
  • Gastric Inhibitory Polypeptide