Cell-mediated immunity in pregnant women

Gynecol Invest. 1976;7(5):280-92. doi: 10.1159/000301389.

Abstract

Phytohemagglutinin-induced lymphocyte transformation (PHA-T) was depressed in pregnant women, as compared with that in nonpregnant women. Pregnancy serum had a suppressive action on PHA-T which was enhanced with the advance in pregnancy. Hydrocortisone, progesterone, alpha-fetoprotein and trophoblast-specific antigen, were demonstrated as immune suppressive factors. From these results, it was concluded that cell-mediated immunity might be reduced in pregnant women and that this reduction might be one of the causes for the maintenance of pregnancy.

MeSH terms

  • Antigens
  • Chorionic Gonadotropin / blood
  • Chorionic Gonadotropin / pharmacology
  • Female
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / pharmacology
  • Immunity, Cellular* / drug effects
  • Lectins / pharmacology
  • Lymphocyte Activation / drug effects
  • Lymphocyte Culture Test, Mixed
  • Lymphocytes / immunology
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Pregnancy*
  • Progesterone / blood
  • Progesterone / pharmacology
  • Trophoblasts / immunology
  • alpha-Fetoproteins / analysis

Substances

  • Antigens
  • Chorionic Gonadotropin
  • Lectins
  • alpha-Fetoproteins
  • Progesterone
  • Hydrocortisone