Plasma kallikrein activity in human diabetes mellitus

Metabolism. 1983 Jun;32(6):540-2. doi: 10.1016/0026-0495(83)90022-7.


It has recently been observed that administration of bradykinin to diabetic patients improves peripheral glucose utilization. To verify whether there is an alteration of the kallikrein-kinin system in human diabetes, plasma kallikrein activity was measured in 47 diabetic patients and in 20 control subjects. In diabetics plasma kallikrein activity was significantly higher than in controls: 1.04 +/- 0.04 U/ml (p less than 0.001). Although they do not refute the hypothesis that there is an alteration of the kallikrein-kinin system in diabetes mellitus, these findings do not support such a hypothesis either. Increased synthesis of plasma kallikrein activity may be due to increased synthesis of carbohydrate-protein compounds in diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / analysis
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / enzymology*
  • Female
  • Humans
  • Insulin / therapeutic use
  • Kallikreins / blood*
  • Male
  • Middle Aged


  • Blood Glucose
  • Insulin
  • Kallikreins