Activated charcoal in tricyclic antidepressant poisoning: pilot controlled clinical trial

Hum Toxicol. 1983 Apr;2(2):205-9. doi: 10.1177/096032718300200205.


1 A randomised clinical trial was carried out to assess the effects of activated charcoal in the management of suspected tricyclic antidepressant poisoning. 2 Forty-eight patients entered the study, twenty receiving supportive care plus activated charcoal (10 g) and twenty-eight supportive care alone. 3 Drug screening showed that only seventeen patients had taken tricyclic antidepressants alone. 4 Activated charcoal had no effect on either the rate of lightening of coma or the fall in plasma antidepressant concentration in the 'pure' tricyclic antidepressant poisoning group. 5 No serious side-effects of activated charcoal were reported.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antidepressive Agents, Tricyclic / blood
  • Antidepressive Agents, Tricyclic / poisoning*
  • Charcoal / therapeutic use*
  • Child
  • Clinical Trials as Topic
  • Coma / chemically induced
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Time Factors


  • Antidepressive Agents, Tricyclic
  • Charcoal