Suicidal destruction of cytochrome P-450 during oxidative drug metabolism

Annu Rev Pharmacol Toxicol. 1983:23:481-503. doi: 10.1146/annurev.pa.23.040183.002405.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylene / pharmacology
  • Alkenes / pharmacology
  • Alkylation
  • Animals
  • Biotransformation
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Interactions
  • Heme / biosynthesis
  • Heme / metabolism
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Liver / enzymology
  • Oxidation-Reduction
  • Substrate Specificity

Substances

  • Alkenes
  • Cytochrome P-450 Enzyme Inhibitors
  • Isoenzymes
  • Heme
  • Cytochrome P-450 Enzyme System
  • Acetylene