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. 1983 Sep;57(3):671-3.
doi: 10.1210/jcem-57-3-671.

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men

D C Cumming et al. J Clin Endocrinol Metab. .

Abstract

The effect of acute activation of the ACTH-adrenal axis on circulating testosterone (T) levels was investigated. Elevation of circulating cortisol resulting from insulin-induced hypoglycemia or the administration of hydrocortisone was followed by a rapid decrease in serum T levels, without accompanying changes in LH or PRL. These findings suggest that hypercortisolism of endogenous or exogenous sources suppresses T secretion by a direct action on the testis. This adrenal-testicular axis may have biological implications on the reproductive adaptation to stress.

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