Cefuroxime: antimicrobial activity, Pharmacology, and clinical efficacy

Ther Drug Monit. 1983 Jun;5(2):149-60.


The antimicrobial activity, pharmacology, toxicity, and clinical efficacy of cefuroxime are reviewed. Cefuroxime has a second-generation cephalosporin spectrum of activity similar to cefamandole. Addition of a methoxyimino side chain has enhanced its beta-lactamase stability. Cefuroxime is active against certain cephalothin-, cefamandole-, and gentamicin-resistant bacteria. Cefuroxime has an extended half-life which allows dosing every 8 h. If penetrates into bodily tissues and fluids, including the cerebrospinal fluid, in therapeutic concentrations. Cefuroxime has been used successfully in the treatment of meningitis; sepsis; urinary tract, bone and joint, pulmonary, skin, and soft tissue infections; and gonorrhea. Competitive pricing of cefuroxime should provide a cost-effective substitute for cefamandole and, in certain situations, third-generation cephalosporins.

Publication types

  • Review

MeSH terms

  • Cefuroxime* / metabolism
  • Cefuroxime* / pharmacology
  • Cefuroxime* / therapeutic use
  • Cephalosporins* / metabolism
  • Cephalosporins* / pharmacology
  • Enterobacteriaceae / drug effects
  • Gonorrhea / drug therapy
  • Humans
  • Kinetics
  • Lung Diseases / drug therapy
  • Meningitis / drug therapy
  • Premedication
  • Staphylococcus / drug effects
  • Streptococcus / drug effects
  • Tissue Distribution


  • Cephalosporins
  • Cefuroxime