Half-life time and control frequency of vitamin K-dependent Coagulation factors. Theoretical considerations on the place of factor VII in the control of oral anticoagulation therapy

Haemostasis. 1983;13(3):201-8. doi: 10.1159/000214728.

Abstract

A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anti-coagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticoagulants / administration & dosage*
  • Blood Coagulation Disorders / blood
  • Blood Coagulation Disorders / diagnosis
  • Blood Coagulation Disorders / drug therapy*
  • Cattle
  • Factor IX / biosynthesis
  • Factor IXa
  • Factor VII / analysis*
  • Factor VII / biosynthesis
  • Factor VII / physiology
  • Factor VIIa
  • Factor X / biosynthesis
  • Factor X / physiology
  • Factor Xa
  • Half-Life
  • Humans
  • Kinetics
  • Models, Biological
  • Vitamin K / blood*

Substances

  • Anticoagulants
  • Vitamin K
  • Factor VII
  • Factor IX
  • Factor X
  • Factor VIIa
  • Factor IXa
  • Factor Xa