Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites

Prostaglandins. 1978 Feb;15(2):325-31. doi: 10.1016/0090-6980(78)90172-7.


The relative potencies of the prostaglandins A1, A2, E1, E2, F2alpha and their 15-keto-, 15-keto-13,14-dihydro-, and 13,14-dihydro-metabolites were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated PO2. All the prostaglandins (except PGF2alpha and its 15-keto-metabolites) relaxed the tissue. However, only PGE1, E2, and their 13,14-dihydro-metabolites, were effective at concentrations below 10(-8) M. Therefore, events that alter metabolism of circulating PGs in the perinatal period may have significant effects on the relative patency or closure of the ductus arteriosus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Ductus Arteriosus / drug effects*
  • Muscle Contraction / drug effects
  • Muscle Relaxation / drug effects
  • Oxygen
  • Partial Pressure
  • Prostaglandins / pharmacology*
  • Prostaglandins A / pharmacology
  • Prostaglandins E / pharmacology
  • Prostaglandins F / pharmacology
  • Sheep


  • Prostaglandins
  • Prostaglandins A
  • Prostaglandins E
  • Prostaglandins F
  • Oxygen