Administration of gallium nitrate by continuous infusion: lack of chronic nephrotoxicity confirmed by studies of enzymuria and beta 2-microglobulinuria

Cancer Treat Rep. 1983 Oct;67(10):941-2.


Enzymuria and beta 2-microglobulinuria are sensitive markers of injury to renal tubular cells. We evaluated these markers in 41 patients with advanced malignant lymphoma who received gallium nitrate administered as a continuous infusion during a recent phase I-II study. In contrast to our findings with cisplatin, we observed no significant increase in enzyme excretion or beta 2-microglobulinuria in these patients even after long-term treatment. Our results indicate that gallium nitrate administered by infusion does not produce cumulative renal tubular toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylglucosaminidase / urine
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Gallium / administration & dosage
  • Gallium / adverse effects*
  • Humans
  • Kidney / drug effects*
  • Leucyl Aminopeptidase / urine
  • beta 2-Microglobulin / urine*


  • Antineoplastic Agents
  • beta 2-Microglobulin
  • Gallium
  • Acetylglucosaminidase
  • Leucyl Aminopeptidase
  • gallium nitrate