Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

Nature. 1983 Oct 27-Nov 2;305(5937):771-5. doi: 10.1038/305771a0.


Rat cells transformed by the highly oncogenic adenovirus 12 lack at least two cellular proteins which are present in cells transformed by the non-oncogenic adenovirus 5 and in untransformed cells. One protein has been identified as the heavy chain of the rat class I major histocompatibility complex. This finding may explain the difference in oncogenicity between adenoviral species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae*
  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Viral
  • Electrophoresis, Polyacrylamide Gel
  • Histocompatibility Antigens / analysis*
  • Major Histocompatibility Complex*
  • Membrane Proteins / analysis
  • Mice
  • Molecular Weight
  • Oncogenic Viruses*
  • Protein Biosynthesis
  • Rats
  • beta 2-Microglobulin / analysis


  • Histocompatibility Antigens
  • Membrane Proteins
  • beta 2-Microglobulin