Evidence for the presence of a histaminergic neuron system in the rat brain: an immunohistochemical analysis

Neurosci Lett. 1983 Sep 9;39(3):249-54. doi: 10.1016/0304-3940(83)90308-7.


Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. HDC-like immunoreactive (HDCI) structures could be detected in the brain as well as in peritoneal mast cells and basal-granulated cells in deep crypts of the gastric mucosa of rats. Numerous HDCI neurons were found in the posterior hypothalamic area and HDCI nerve fibers with a varicose appearance of fluorescence were widely distributed in various regions of the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / immunology
  • Brain / cytology
  • Brain / physiology*
  • Fluorescent Antibody Technique
  • Histamine / physiology*
  • Histidine Decarboxylase / immunology
  • Histocytochemistry
  • Male
  • Neurons / physiology*
  • Rabbits
  • Rats / physiology*
  • Rats, Inbred Strains


  • Antibodies
  • Histamine
  • Histidine Decarboxylase