Antifungal action of rifampin

Rev Infect Dis. Jul-Aug 1983;5 Suppl 3:S614-9. doi: 10.1093/clinids/5.supplement_3.s614.

Abstract

Rifampin and amphotericin B were found to be synergistic in vitro against Saccharomyces cerevisiae, Histoplasma capsulatum, and several species of Aspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed. In vivo, the combination proved more effective than either drug alone against experimental infections with H. capsulatum, Blastomyces dermatitidis, and Aspergillus species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphotericin B / pharmacology
  • Animals
  • Aspergillosis / drug therapy
  • Aspergillus / drug effects*
  • Blastomycosis / drug therapy
  • Drug Synergism
  • Histoplasma / drug effects*
  • Histoplasmosis / drug therapy
  • Mice
  • Rifampin / pharmacology*
  • Saccharomyces cerevisiae / drug effects*

Substances

  • Amphotericin B
  • Rifampin