Role of iron in microbe-host interactions

Rev Infect Dis. Sep-Oct 1983;5 Suppl 4:S759-77. doi: 10.1093/clinids/5.supplement_4.s759.

Abstract

The ability of microorganisms that would like to live in or on mammalian hosts to acquire iron is a critical determinant of the host-parasite interaction. Despite the abundance of iron, its availability to microbes is restricted by the iron-binding and transport systems of the host. The successful commensal or pathogen therefore must express effective systems to compete for its iron. The acquisition of iron is thus essential, although not sufficient, for virulence. This review examines host and microbial iron-acquisition and transport mechanisms in an attempt to stimulate the reader's interest in potential "soft spots" that may be exploited prophylactically and therapeutically.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / pathogenicity*
  • Bacterial Infections / blood
  • Bacterial Infections / drug therapy
  • Bacterial Infections / immunology
  • Bacterial Proteins / biosynthesis
  • Chelating Agents / therapeutic use
  • Ferritins / physiology
  • Hemoglobins / physiology
  • Humans
  • Iron / blood
  • Iron / physiology*
  • Lactoferrin / physiology
  • Neisseria / growth & development
  • Transferrin / physiology
  • Virulence

Substances

  • Bacterial Proteins
  • Chelating Agents
  • Hemoglobins
  • Transferrin
  • Ferritins
  • Iron
  • Lactoferrin