Drug prescribing in renal failure: dosing guidelines for adults

Am J Kidney Dis. 1983 Nov;3(3):155-93. doi: 10.1016/s0272-6386(83)80060-2.


The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency are presented in tabular form. Current medical literature was extensively surveyed to provide as much specific information as possible. When information is lacking, however, recommendations are based on pharmacokinetic variables in normal subjects. Nephrotoxicity, important adverse effects, and special considerations in renal patients are noted. Adjustments are suggested for hemodialysis and peritoneal dialysis when appropriate.

Publication types

  • Review

MeSH terms

  • Adult
  • Drug Administration Schedule
  • Drug Prescriptions / standards*
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Kinetics
  • Pharmaceutical Preparations / administration & dosage*


  • Pharmaceutical Preparations