Split renal function testing using Tc-99m DTPA. A rapid technique for determining differential glomerular filtration

Clin Nucl Med. 1983 Sep;8(9):400-7. doi: 10.1097/00003072-198309000-00003.


The fractional renal uptake of intravenously administered Tc-99m DTPA, within 2 to 3 minutes following radiotracer arrival in the kidneys, is proportional to the glomerular filtration rate (GFR). Thus it is possible to determine total, as well as individual kidney, GFR by a radionuclide technique which needs only six minutes of patient time and requires neither blood nor urine samples. The radionuclide computed GFR correlates extremely well with 24-hour creatinine clearance determinations, and is highly reproducible. This method has been used in nearly 500 split renal function determinations and has provided valuable, accurate information.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Function Tests / methods*
  • Male
  • Middle Aged
  • Pentetic Acid*
  • Radioisotope Renography / methods*
  • Technetium Tc 99m Pentetate
  • Technetium*


  • Technetium
  • Pentetic Acid
  • Technetium Tc 99m Pentetate