Residual C-peptide production in type I diabetes mellitus. A comparison of different methods of assessment and influence on glucose control

Acta Med Scand. 1983;214(3):231-7. doi: 10.1111/j.0954-6820.1983.tb08600.x.


The aims of the present study were to compare various methods for assessment of residual insulin production and to evaluate its role in the metabolic regulation in insulin-dependent, type I diabetes mellitus. Glycosylated hemoglobin (HbA1) was used as a measure of the long-term glycemic control. Twenty-eight patients with type I diabetes mellitus with onset before the age of 30 and with a duration of less than 6 years were studied. C-peptide in plasma in the fasting state, after glucagon stimulation, and the 24-hour urinary excretion were measured. Fasting plasma C-peptide was detected in 61%, and 39% showed a significant rise after glucagon stimulation. The increment correlated negatively with HbA1 (rs = -0.57, p less than 0.001), as did the 24-hour urinary excretion (rs = -0.61, p less than 0.001). The 16 patients with urinary C-peptide values of at least 1 nmol had a mean HbA1 of 8.9 +/- 0.3%, as opposed to 11.6 +/- 0.5% for those excreting less (p less than 0.001). Measurement of the 24-hour urinary excretion of C-peptide provides a reliable method for evaluating residual insulin secretion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis*
  • C-Peptide / blood*
  • C-Peptide / urine
  • Diabetes Mellitus, Type 1 / blood*
  • Female
  • Glucagon / pharmacology
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Insulin / blood
  • Insulin / therapeutic use
  • Lipids / blood
  • Male


  • Blood Glucose
  • C-Peptide
  • Glycated Hemoglobin A
  • Insulin
  • Lipids
  • Glucagon