A case of mania associated with fluoxetine

Am J Psychiatry. 1984 Feb;141(2):280-1. doi: 10.1176/ajp.141.2.280.


A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine. This side effect appears to be a universal property of effective antidepressants, including this new, purely serotonergic agent.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Adult
  • Bipolar Disorder / chemically induced*
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy
  • Female
  • Fluoxetine / adverse effects*
  • Humans
  • Propylamines / adverse effects*


  • Propylamines
  • Fluoxetine