Treatment of acute maxillary sinusitis in childhood: a comparative study of amoxicillin and cefaclor

J Pediatr. 1984 Feb;104(2):297-302. doi: 10.1016/s0022-3476(84)81018-5.


Maxillary sinus aspiration and quantitative culture of the aspirate were performed in 50 patients, ranging in age from 1 to 16 years, with clinical and radiographic evidence of acute sinusitis. Of 79 sinuses aspirated, at least one was found to be infected in 35 (70%) children. Streptococcus pneumoniae, Branhamella catarrhalis, and Haemophilus influenzae were the most common organisms recovered. All H. influenzae were nontypeable. Twenty percent of the H. influenzae and 27% of the B. catarrhalis organisms were beta-lactamase positive and amoxicillin resistant. The subjects received either amoxicillin or cefaclor at a dose of 40 mg/kg/day in three doses for 10 days. The clinical cure rate with amoxicillin was 81%, compared to 78% with cefaclor. Radiographic improvement was similar in both treatment groups. Antibiotic therapy failed in four patients; three had been given amoxicillin, and one cefaclor. In three of these, a beta-lactamase-positive antibiotic-resistant bacterial species was recovered from the maxillary sinus aspirate; the fourth aspirate was sterile.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Amoxicillin / therapeutic use*
  • Cefaclor / therapeutic use*
  • Cephalexin / analogs & derivatives*
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Follow-Up Studies
  • Haemophilus Infections / diagnostic imaging
  • Haemophilus Infections / drug therapy*
  • Humans
  • Infant
  • Maxillary Sinus / diagnostic imaging
  • Radiography
  • Sinusitis / diagnostic imaging
  • Sinusitis / drug therapy*
  • Streptococcal Infections / diagnostic imaging
  • Streptococcal Infections / drug therapy*


  • Cefaclor
  • Amoxicillin
  • Cephalexin