Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis

Nature. 1984 Jan 19-25;307(5948):241-5. doi: 10.1038/307241a0.


The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.

MeSH terms

  • Animals
  • Cell Transformation, Viral*
  • Chickens
  • Gene Expression Regulation
  • Insulin / genetics
  • Leukemia, Experimental / genetics
  • Leukemia, Experimental / microbiology
  • Mutation
  • Oncogenes*
  • Operon
  • Repetitive Sequences, Nucleic Acid
  • Retroviridae / genetics*
  • Transcription, Genetic
  • Viral Envelope Proteins / genetics


  • Insulin
  • Viral Envelope Proteins