Possible treatment of pre-eclampsia with calcium channel blocking agents

Med Hypotheses. 1983 Dec;12(4):303-19. doi: 10.1016/0306-9877(83)90103-2.


A review of the pathophysiology and treatment of pre-eclampsia indicates that vasospasm and vascular hyperreactivity are important elements in the disease process and its control. Five requirements for a therapeutic agent in pre-eclampsia are identified: control of generalized vasospasm, hypertension, and eclamptic convulsions, maintenance of placental perfusion, and lack of adverse effects on the fetus/neonate. Calcium channel blocking agents are well known arteriolar vasodilators and inhibitors of coronary artery vasospasm, and appear to possess qualities relevant to these therapeutic requirements for pre-eclampsia. It is proposed that calcium channel blocking agents may be effective agents in the management of pre-eclampsia.

Publication types

  • Review

MeSH terms

  • Calcium Channel Blockers / therapeutic use*
  • Eclampsia / drug therapy
  • Female
  • Fetus / drug effects
  • Humans
  • Hypertension / drug therapy
  • Nifedipine / therapeutic use
  • Placenta / blood supply
  • Placenta / drug effects
  • Pre-Eclampsia / drug therapy*
  • Pre-Eclampsia / etiology
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy
  • Vasoconstriction / drug effects


  • Calcium Channel Blockers
  • Nifedipine