Role of protein degradation in the regulation of cellular protein content and amino acid pools

Fed Proc. 1984 Apr;43(5):1283-8.

Abstract

A decrease in the rate of protein degradation contributes to the accumulation of cellular protein during growth or storage of dietary amino acids. Examples of this process in the liver of live mice are reviewed. One aspect of this regulation is the direct effect of amino acids on the rate of protein breakdown. At least in the case of histidine starvation in Chinese hamster ovary cells, the regulatory mechanism recognizes the level of aminoacylation of tRNA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Animals
  • Cell Line
  • Cells / metabolism*
  • Cricetinae
  • Cycloheximide / pharmacology
  • Dietary Proteins / metabolism
  • Escherichia coli / metabolism
  • Female
  • Histidine-tRNA Ligase / metabolism
  • Histidinol / pharmacology
  • Hypertrophy / metabolism
  • Kinetics
  • Liver / growth & development
  • Liver / metabolism
  • Liver Regeneration
  • Mice
  • Muscles / metabolism
  • Ovary
  • Protein Biosynthesis
  • Proteins / metabolism*
  • RNA, Transfer / metabolism
  • RNA, Transfer, Amino Acyl / metabolism
  • Starvation / metabolism

Substances

  • Amino Acids
  • Dietary Proteins
  • Proteins
  • RNA, Transfer, Amino Acyl
  • Histidinol
  • RNA, Transfer
  • Cycloheximide
  • Histidine-tRNA Ligase