Cerebral tumors induced by transplacental ENU: study of the different tumoral stages, particularly of early proliferations

Acta Neuropathol. 1978 Jan 19;41(1):27-31. doi: 10.1007/BF00689553.


Experimental cerebral tumors have been induced by transplacental ENU. A systematic diachronic study of the brains has been performed starting from the 15th day of extrauterine life. The tumoral lesions firstly appear as "early stage proliferations" or oligodendroglial foci and develop as glial micro- and macrotumors or as isomorphic and polymorphic oligodendrogliomas respectively. Neurinomas appear later than glial tumors. The duration of the different lesions is sketched out. The usefulness of the model for chemotherapy studies is discussed.

MeSH terms

  • Animals
  • Brain Neoplasms / chemically induced*
  • Brain Neoplasms / pathology
  • Ethylnitrosourea*
  • Female
  • Glioma / chemically induced
  • Glioma / pathology
  • Maternal-Fetal Exchange*
  • Neoplasms, Experimental / chemically induced
  • Neurilemmoma / chemically induced
  • Neurilemmoma / pathology
  • Nitrosourea Compounds*
  • Oligodendroglioma / chemically induced
  • Oligodendroglioma / pathology
  • Pregnancy
  • Rats
  • Time Factors


  • Nitrosourea Compounds
  • Ethylnitrosourea