An experimental evaluation of central vs. peripheral injection for intravenous digital subtraction angiography (IV-DSA)

Invest Radiol. 1984 Jan-Feb;19(1):30-5. doi: 10.1097/00004424-198401000-00007.

Abstract

At a given radiation dosage and field of view, five variables are under meaningful control for intravenous digital subtraction angiography (IV-DSA): concentration and quantity of contrast media injected, volume of injectate, rate of injection, and site of injection. Some controversy exists regarding the selection of a central vs. a peripheral injection site for IV-DSA. This study determined the influence of the site of injection on the peak and width of the arterial time-concentration curve produced by contrast media. Using a noninvasive, in vivo, quantitative x-ray measurement method, 36 separate injections (10 ml of ioxaglate at 8 ml/sec) were administered into the cephalic vein, subclavian vein, and main pulmonary artery in dogs. Injection sites were varied using a Latin-square experimental design. Cardiac output, central blood volume and the peak and width of the contrast media time-concentration curves were measured. The average peak enhancement was greatest for the pulmonary artery injection site. Normalizing peak and width values to make the pulmonary artery values 100%, the average peak values for injections into the subclavian vein and cephalic vein were 93% and 56%, and the average widths were 141% and 163%, respectively. These data support the use of a more central injection site for optimizing IV-DSA examinations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiography / methods*
  • Animals
  • Computers
  • Contrast Media / administration & dosage*
  • Dogs
  • Forelimb / blood supply
  • Injections, Intra-Arterial
  • Injections, Intravenous
  • Ioxaglic Acid
  • Pulmonary Artery
  • Subclavian Vein
  • Subtraction Technique
  • Triiodobenzoic Acids / administration & dosage
  • Veins

Substances

  • Contrast Media
  • Triiodobenzoic Acids
  • Ioxaglic Acid