Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]

Acta Neuropathol. 1978 Feb 20;41(2):85-9. doi: 10.1007/BF00689757.


A new animal model for the study of diabetic neuropathy is presented. The homozygote (db/db) of the mouse strain C57BL/Ks shows severe diabetes with longstanding hyperglycemia. Electrophysiological studies showed severely decreased motor nerve conduction velocity. Morphometric examination of sensory and motor nerves at different levels revealed absence of large myelinated fibers, with morphological features indicative of axonal atrophy.

MeSH terms

  • Animals
  • Atrophy
  • Axons
  • Diabetic Neuropathies / pathology*
  • Disease Models, Animal*
  • Female
  • Homozygote
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Nerve Fibers, Myelinated
  • Neural Conduction
  • Peripheral Nerves / pathology