Antibiotic prophylaxis in neurosurgery. A randomized controlled trial

J Neurosurg. 1984 Apr;60(4):724-6. doi: 10.3171/jns.1984.60.4.0724.


A randomized trial was performed to support the contention that prophylactic antibiotics can reduce the incidence of postoperative neurosurgical wound infections. The regime outlined by Malis was followed. Vancomycin and gentamicin were administered systemically just prior to surgery and streptomycin was added to the irrigating solution. Patients were randomly assigned to two groups: control and treated. The infection rate in the control group was 3.5% and in the treated group 0.5%.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Clinical Trials as Topic
  • Gentamicins / therapeutic use
  • Humans
  • Middle Aged
  • Random Allocation
  • Streptomycin / therapeutic use
  • Surgical Wound Infection / prevention & control*
  • Vancomycin / therapeutic use


  • Anti-Bacterial Agents
  • Gentamicins
  • Vancomycin
  • Streptomycin