Disposition and metabolism of MHPG in humans: application to studies in depression

Pharmacopsychiatry. 1984 Jan;17(1):3-8. doi: 10.1055/s-2007-1017399.


MHPG is formed from norepinephrine metabolized throughout the body; its levels in plasma reflect total norepinephrine metabolism. Over half of the MHPG, is converted to VMA. Less than 20% of MHPG is derived from brain norepinephrine and urinary excretion of this metabolite cannot be used as a measure of brain norepinephrine metabolism. Because unconjugated MHPG is readily diffusable, there is a free exchange of this metabolite among plasma, cerebrospinal fluid, and nerve tissues (including brain and spinal cord). The CSF MHPG levels, after appropriately correction for the plasma contribution of the metabolite, reflect its rate of formation in the central nervous system.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Diseases / metabolism
  • Adrenal Medulla / metabolism
  • Autonomic Nervous System Diseases / metabolism
  • Biotransformation
  • Body Fluids / metabolism
  • Catecholamines / metabolism
  • Depressive Disorder / metabolism*
  • Glycols / metabolism*
  • Humans
  • Kinetics
  • Methoxyhydroxyphenylglycol / metabolism*
  • Norepinephrine / metabolism
  • Vanilmandelic Acid / metabolism


  • Catecholamines
  • Glycols
  • Methoxyhydroxyphenylglycol
  • Vanilmandelic Acid
  • Norepinephrine