Diabetic neuropathy

Ann Neurol. 1984 Jan;15(1):2-12. doi: 10.1002/ana.410150103.


Peripheral nerve disorders are important late complications of diabetes mellitus. Polyneuropathy, which may involve varying proportions of sensory, motor, and autonomic fibers, is considered the consequence of metabolic derangements that result from chronic hyperglycemia. Symmetrical proximal motor neuropathy ("diabetic amyotrophy") also may have a metabolic basis. Mononeuropathies in diabetes may have an ischemic or compressive cause. Advances have been made in understanding the biochemical basis for diabetic polyneuropathy. The treatment of symptomatic diabetic neuropathy should be directed toward long-term normalization of blood glucose until more specific therapies become available.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Autonomic Nervous System Diseases / physiopathology
  • Diabetes Mellitus / physiopathology
  • Diabetic Neuropathies / pathology
  • Diabetic Neuropathies / physiopathology*
  • Diabetic Neuropathies / therapy
  • Humans
  • Hyperglycemia / complications
  • Intercostal Nerves / physiopathology
  • Nerve Compression Syndromes / physiopathology
  • Neural Conduction
  • Neuromuscular Diseases / physiopathology
  • Oculomotor Nerve / physiopathology
  • Sensation / physiology