Type 2 (non-insulin-dependent) diabetes mellitus and coronary heart disease-chicken, egg or neither?

Diabetologia. 1984 Feb;26(2):99-102. doi: 10.1007/BF00281114.


review of the literature yields much evidence against a correlation between duration of non-insulin-dependent diabetes mellitus (Type 2 diabetes) and the degree of coronary atherosclerosis or the risk of clinically evident coronary heart disease (CHD). Furthermore, an increased risk of CHD, similar to that in previously diagnosed diabetic subjects, has been demonstrated in persons with impaired glucose tolerance. These observations suggest that an increased risk of CHD is not a consequence of the development of diabetes (i.e. persistent hyperglycaemia). It is more likely that diabetes develops in individuals who already possess characteristics which increase the risk of CHD in addition to the risk of developing diabetes.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arteriosclerosis / complications*
  • Arteriosclerosis / mortality
  • Coronary Disease / complications*
  • Coronary Disease / mortality
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / mortality
  • Diabetic Angiopathies / complications*
  • Diabetic Angiopathies / mortality
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Hyperglycemia / complications*
  • Male
  • Middle Aged
  • Prediabetic State / diagnosis
  • Risk
  • Time Factors