The ethanol withdrawal syndrome: a consequence of lack of substrate for a cerebral Krebs-cycle

J Theor Biol. 1984 Feb 7;106(3):375-81. doi: 10.1016/0022-5193(84)90036-5.

Abstract

The hypothesis is advanced that the ethanol withdrawal syndrome is a manifestation of dependence by a cerebral Krebs-cycle on substrates which are readily available during ethanol addiction but which are relatively unavailable during withdrawal.

Publication types

  • Review

MeSH terms

  • 3-Hydroxybutyric Acid
  • Animals
  • Brain / metabolism*
  • Butyrates / metabolism
  • Citric Acid Cycle*
  • Ethanol / adverse effects*
  • Humans
  • Hydroxybutyrates / metabolism
  • Lactates / metabolism
  • Rats
  • Substance Withdrawal Syndrome / drug therapy
  • Substance Withdrawal Syndrome / metabolism*

Substances

  • Butyrates
  • Hydroxybutyrates
  • Lactates
  • Ethanol
  • 3-Hydroxybutyric Acid