Abstract
To determine whether lithium can shorten chemotherapy-induced neutropenia, 35 adult patients with newly diagnosed acute myeloid leukemia undergoing initial chemotherapy were randomized either to receive oral lithium started at the time of biopsy-proven hypoplasia or to receive no lithium. This study failed to show statistically significant shortening of the duration of chemotherapy-induced neutropenia in the lithium treatment group.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Agranulocytosis / drug therapy*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Clinical Trials as Topic
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Female
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Humans
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Leukemia, Myeloid, Acute / drug therapy*
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Leukocyte Count
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Lithium / therapeutic use*
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Male
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Neutropenia / chemically induced
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Neutropenia / drug therapy*
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Random Allocation