Lithium treatment in adults with acute myeloid leukemia receiving chemotherapy

Med Pediatr Oncol. 1984;12(3):169-72. doi: 10.1002/mpo.2950120305.


To determine whether lithium can shorten chemotherapy-induced neutropenia, 35 adult patients with newly diagnosed acute myeloid leukemia undergoing initial chemotherapy were randomized either to receive oral lithium started at the time of biopsy-proven hypoplasia or to receive no lithium. This study failed to show statistically significant shortening of the duration of chemotherapy-induced neutropenia in the lithium treatment group.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Agranulocytosis / drug therapy*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Clinical Trials as Topic
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukocyte Count
  • Lithium / therapeutic use*
  • Male
  • Neutropenia / chemically induced
  • Neutropenia / drug therapy*
  • Random Allocation


  • Lithium