A comparison of the effect of flurbiprofen, dexamethasone, and placebo on cyclocryotherapy-induced inflammation

Ophthalmic Surg. 1984 May;15(5):394-9.


A double-blind study was performed to compare the effects of a placebo, a topical corticosteroid, and a topical non-steroidal prostaglandin inhibitor on the inflammation and the course of intraocular pressure that follows cyclocryotherapy. Flurbiprofen 0.03%, dexamethasone phosphate 0.1%, and a sterile vehicle placebo were used both pre and postoperatively. Less anterior chamber flare was seen in flurbiprofen-treated eyes than those receiving placebo, but only at four weeks after surgery. More erythema was seen in flurbiprofen-treated eyes than in those receiving dexamethasone. Significance was approached showing more anterior chamber cells in placebo-treated eyes than in steroid-treated eyes. Cyclocryotherapy produces inflammation which is difficult to control with topically administered medications.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anterior Chamber / drug effects
  • Clinical Trials as Topic
  • Dexamethasone / pharmacology
  • Dexamethasone / therapeutic use*
  • Double-Blind Method
  • Female
  • Flurbiprofen / pharmacology
  • Flurbiprofen / therapeutic use*
  • Glaucoma / drug therapy*
  • Glaucoma / surgery
  • Humans
  • Inflammation / drug therapy
  • Male
  • Middle Aged
  • Postoperative Complications / drug therapy
  • Propionates / therapeutic use*


  • Propionates
  • Flurbiprofen
  • Dexamethasone