Immunohistochemical localization of secretory component in the liver of guinea pigs and dogs versus rats, rabbits, and mice

Scand J Immunol. 1984 May;19(5):425-34. doi: 10.1111/j.1365-3083.1984.tb00951.x.


Secretory component (SC) was localized in the liver of guinea pigs, dogs, rabbits, rats, and mice. In rabbits, rats, and mice SC localized predominantly in bile canaliculi and on hepatocyte sinusoidal membranes but was doubtful in cholangiocytes . In dogs and guinea pigs SC-staining was not detected in/on hepatocytes and canaliculi but was strong in/on cholangiocytes , as reported for humans. In guinea pigs IgA biliary output was small (0.23 mg/kg/day), as for dogs and humans, and below IgG output (1.4 mg), in contrast to rats, whose IgA biliary output (38 mg/kg/day) was much larger than IgG output (2mg). Biliary obstruction in guinea pigs induced only minor increases in serum IgA (+ 26% over 24 h), as reported for dogs and humans, in contrast to rats (+ 800% over 24h) and rabbits. Hepatocyte SC expression correlates with IgA hepatobiliary excretion, being low in guinea pigs, dogs, and humans but high in rats, rabbits, and mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bile / immunology
  • Bile / metabolism
  • Bile Canaliculi / immunology
  • Bile Ducts / immunology
  • Cell Membrane / immunology
  • Cholestasis / immunology
  • Dogs
  • Guinea Pigs
  • Histocytochemistry
  • Immunoenzyme Techniques
  • Immunoglobulin A / metabolism
  • Immunoglobulin Fragments / analysis*
  • Liver / cytology
  • Liver / immunology*
  • Mice
  • Rabbits
  • Rats
  • Secretory Component / analysis*
  • Secretory Component / metabolism


  • Immunoglobulin A
  • Immunoglobulin Fragments
  • Secretory Component