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Clinical Trial
, 17 (5), 521-4

Objective Evaluation of Dextromethorphan and Glaucine as Antitussive Agents

Clinical Trial

Objective Evaluation of Dextromethorphan and Glaucine as Antitussive Agents

K H Rühle et al. Br J Clin Pharmacol.


Twenty-four inpatients affected by chronic cough completed a single-dose double-blind cross-over study of placebo, glaucine 30 mg and dextromethorphan 30 mg. The study was carried out using a balanced incomplete block design, each patient receiving two of the three experimental treatments. Objective evaluation of cough was ensured by means of a writing cough recorder. Coughs after dextromethorphan and glaucine were fewer than coughs after placebo: however only glaucine was significantly different from placebo in reducing coughs. Treatments were well tolerated: clinical results included a reduction in pulse rate after both dextromethorphan and glaucine , and a large number of patients reporting side effects after dextromethorphan administration.

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