Syntheses With Isotopically Labelled Carbon. Methyl Iodide, Formaldehyde and Cyanide

Int J Appl Radiat Isot. 1984 May;35(5):323-35. doi: 10.1016/0020-708x(84)90036-x.

Abstract

Many of the uniquely labelled synthetic precursors currently employed in the design of sophisticated radiolabelled compounds have their origins in the field of hot atom chemistry. Particularly, the development during the past few years of automated, on-line synthetic procedures which combine the nuclear reaction, hot atom and classical chemistry, and rapid purification methods has allowed the incorporation of useful radionuclides into suitable compounds of chemical and biochemical interest. The application of isotopically labelled methyl iodide, formaldehyde, and cyanide anion as synthetic intermediates in research involving human physiology and nuclear medicine, as well as their contributions to other scientific methodology, is reviewed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amines
  • Amino Acids
  • Carbon Radioisotopes*
  • Carboxylic Acids
  • Cyanides*
  • Enzymes
  • Formaldehyde*
  • Humans
  • Hydrocarbons, Iodinated*
  • Indicators and Reagents
  • Isotope Labeling*
  • Magnetic Resonance Spectroscopy
  • Nitriles
  • Proteins
  • Viruses

Substances

  • Amines
  • Amino Acids
  • Carbon Radioisotopes
  • Carboxylic Acids
  • Cyanides
  • Enzymes
  • Hydrocarbons, Iodinated
  • Indicators and Reagents
  • Nitriles
  • Proteins
  • Formaldehyde
  • methyl iodide