Effect of volume and rate of contrast medium injection on intravenous digital subtraction angiographic contrast medium curves

J Am Coll Cardiol. 1984 Aug;4(2):308-15. doi: 10.1016/s0735-1097(84)80219-3.


The image quality of temporal (mask mode) intravenous digital subtraction angiography is directly dependent on the shape of arterial time-concentration curves produced by the intravenous injection of contrast medium. Curves that are narrow and tall minimize motion artifact (misregistration) and maximize contrast enhancement (pre- and postcontrast differences). To determine the effects of rate and volume of injection of contrast medium on intravenous digital subtraction angiographic curves, ioxaglate (Hexabrix), a monoacidic ionic dimer, was injected into large mongrel dogs. Quantitative measurements of opacification were made over time in the femoral arteries using a modified General Electric CT/T scanner. Peak opacification was directly proportional to the volume of contrast medium injected. Curve width was not affected by increasing volume of injection. At rates below a critical point, slower injection rates produced progressively shorter and wider arterial time-concentration curves. Above that critical point, increasing the rate of injection did not affect either curve width or curve peak.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiography / methods*
  • Animals
  • Contrast Media / administration & dosage*
  • Dogs
  • Femoral Artery / diagnostic imaging
  • Heart Atria / diagnostic imaging
  • Injections, Intravenous / methods
  • Ioxaglic Acid
  • Subtraction Technique*
  • Triiodobenzoic Acids / administration & dosage


  • Contrast Media
  • Triiodobenzoic Acids
  • Ioxaglic Acid